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Research - Model Systems in Biology: History, Philosophy, and Practical Concerns

Description

Book Synopsis: How biomedical research using various animal species and in vitro cellular systems has resulted in both major successes and translational failure.In Model Systems in Biology, comparative neurobiologist Georg Striedter examines how biomedical researchers have used animal species and in vitro cellular systems to understand and develop treatments for human diseases ranging from cancer and polio to Alzheimer's disease and schizophrenia. Although there have been some major successes, much of this "translational" research on model systems has failed to generalize to humans. Striedter explores the history of such research, focusing on the models used and considering the question of model selection from a variety of perspectives—the philosophical, the historical, and that of practicing biologists. Striedter reviews some philosophical concepts and ethical issues, including concerns over animal suffering and the compromises that result. He traces the history of the most widely used animal and in vitro models, describing how they compete with one another in a changing ecosystem of models. He examines how therapies for bacterial and viral infections, cancer, cardiovascular diseases, and neurological disorders have been developed using animal and cell culture models—and how research into these diseases has both taken advantage of and been hindered by model system differences. Finally, Striedter argues for a "big tent" biology, in which a diverse set of models and research strategies can coexist productively.

Details

If you're a biomedical researcher looking to understand and develop treatments for human diseases, then you need to get your hands on Model Systems in Biology. This book by comparative neurobiologist Georg Striedter takes a deep dive into the history, philosophy, and practical concerns of using animal species and in vitro cellular systems in biomedical research. With a focus on major successes and translational failures, Striedter uncovers the secrets behind why some research has been successful while others have failed to generalize to humans.

One of the most intriguing aspects of Model Systems in Biology is the exploration of model selection. Striedter delves into the philosophical, historical, and practical considerations that researchers face when choosing which models to use. By understanding the different perspectives and ethical issues, such as animal suffering and compromises, you'll gain a more comprehensive understanding of the research landscape.

Throughout the book, Striedter takes you on a journey through the history of the most widely used animal and in vitro models. He reveals how these models have competed with each other in a constantly changing ecosystem. By learning about their evolution and competition, you'll be better equipped to make informed decisions in your own research.

Model Systems in Biology goes beyond just discussing the history and philosophy. Striedter showcases real-world examples of how therapies for diseases like bacterial and viral infections, cancer, cardiovascular diseases, and neurological disorders have been developed using animal and cell culture models. You'll gain valuable insights into the opportunities and challenges that arise from model system differences.

In the end, Striedter makes a strong case for a "big tent" biology approach, where a diverse set of models and research strategies can thrive together. By embracing this approach, you'll have a more holistic view of biomedical research and be able to uncover new possibilities for advancing medical treatments.

Ready to expand your knowledge and take your research to the next level? Don't miss out on the valuable insights and perspectives in Model Systems in Biology. Click here to get your copy now!

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